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1. JP2021080273 - CONJUGATE OF MINOXIDIL AND PEPTIDE

Office
Japan
Application Number 2021025068
Application Date 19.02.2021
Publication Number 2021080273
Publication Date 27.05.2021
Publication Kind A
IPC
C07K 7/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
A61K 31/506
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61P 17/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
14for baldness or alopecia
A61Q 7/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
7Preparations for affecting hair growth
A61K 8/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
CPC
A61K 47/50
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61P 17/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
14for baldness or alopecia
A61K 8/49
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
A61K 8/4953
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
494with more than one nitrogen as the only hetero atom
4953containing pyrimidine ring derivatives, e.g. minoxidil
A61K 8/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
Applicants CAREGEN CO LTD
ケアジェン カンパニー,リミテッド
Inventors CHUNG YONG JI
チョン ヨンジ
KIM EUN MI
キム ウンミ
Agents 特許業務法人大谷特許事務所
Title
(EN) CONJUGATE OF MINOXIDIL AND PEPTIDE
(JA) ミノキシジルとペプチドの結合体
Abstract
(EN)

PROBLEM TO BE SOLVED: To provide materials which can have a function for preventing hair loss and/or promoting hair growth, which is the same or better as compared with that of conventional hair growth agents, and which have better physiological properties such as stability to water than them.

SOLUTION: The present invention relates to a composition for preventing hair loss, and more particularly, a compound having a structure in which minoxidil and a peptide are chemically linked, and to a pharmaceutical composition or cosmetic composition for preventing hair loss or promoting hair growth containing the same. Since the compound having a structure in which minoxidil and a peptide of the present invention are chemically linked is not only excellent in physiological activities, such as improving hair loss, promoting hair growth, and promoting cell growth, but also excellent in stability in water, it may be usefully used as a composition for preventing hair loss and promoting hair growth.

SELECTED DRAWING: Figure 7

COPYRIGHT: (C)2021,JPO&INPIT


(JA)

【課題】従来の発毛剤と比べ、同一であるかさらに優れた脱毛の防止及び/又は発毛促進の機能ができるとともに、それらより水に対する安定性などの生理学的特性に優れる物質を提供すること
【解決手段】本発明は、脱毛防止用組成物に関し、より詳細には、ミノキシジルとペプチドが化学的に連結された構造を有する化合物、及びこれを含む脱毛防止又は発毛促進用薬学的組成物又は化粧料組成物に関する。本発明のミノキシジルとペプチドが化学的に連結された構造を有する化合物は、脱毛の改善、発毛の促進、細胞成長の促進などのような生理活性に優れるだけでなく、水での安定性に優れるので、脱毛防止及び発毛促進用組成物として有用に用いられてよい。
【選択図】図7


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