JP2020114854 INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS

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Application Number 2020061428

Application Date 30.03.2020

Publication Number 2020114854

Publication Date 30.07.2020

Publication Kind A

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Applicants XYPHOS BIOSCIENCES INC
クシフォス　バイオサイエンシズ　インコーポレイティド

Inventors KYLE LANDGRAF
カイル　ランドグラフ
DANIEL P STEIGER
ダニエル　スタイガー
STEVEN R WILLIAMS
スティーブン　アール．ウィリアムズ
DAVID W MARTIN JR
デイビッド　ダブリュ．マーティン

Agents 青木　篤
石田　敬
福本　積
古賀　哲次
渡辺　陽一
武居　良太郎
津田　英直

Priority Data 03620884 07.11.1956 US

Title

(EN) INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS

(JA) 抗体の挿入可能な可変フラグメントおよびＮＫＧ２Ｄリガンドの改変Α１－Α２ドメイン

Abstract

(EN)

PROBLEM TO BE SOLVED: To provide, generally, polypeptides having specific antigen-binding properties of Fv domains.

SOLUTION: This application relates to production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified α1-α2 domains of NKG2D ligands.

SELECTED DRAWING: Figure 12

(JA)

【課題】本出願は、概して、Ｆｖドメインの特異的な抗原結合性特性を有するポリペプチドの提供に関する。
【解決手段】本出願は、Ｆｖドメインの特異的な抗原結合性特性を有するポリペプチド例えば抗体の挿入可能な可変フラグメント、およびＮＫＧ２Ｄリガンドの改変α１−α２ドメインの製造に関する。
【選択図】図１２

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants
2803	against the immunoglobulin superfamily
2818	against CD28 or CD152

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants
2851	against the lectin superfamily, e.g. CD23, CD72

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants
2863	against receptors for growth factors, growth regulators

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1. JP2020114854 - INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12	Antivirals

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
30	characterized by aspects of specificity or valency
31	multispecific

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
60	characterized by non-natural combinations of immunoglobulin fragments
62	comprising only variable region components
622	Single chain antibody (scFv)

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
70	characterized by effect upon binding to a cell or to an antigen
73	Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
30	characterized by aspects of specificity or valency
31	multispecific