JP2020114238 INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS

Settings

Stemming

Single Family Member

Include NPL

Feedback

Goto Application

Office

Japan

Application Number 2020060639

Application Date 30.03.2020

Publication Number 2020114238

Publication Date 30.07.2020

Grant Number 7132967

Grant Date 30.08.2022

Publication Kind B1

IPC

View more classifications

View less classifications

CPC

View more classifications

View less classifications

Applicants XYPHOS BIOSCIENCES INC
クシフォス　バイオサイエンシズ　インコーポレイティド

Inventors KYLE LANDGRAF
カイル　ランドグラフ
DANIEL P STEIGER
ダニエル　スタイガー
STEVEN R WILLIAMS
スティーブン　アール．ウィリアムズ
DAVID W MARTIN JR
デイビッド　ダブリュ．マーティン

Agents 青木　篤
石田　敬
福本　積
古賀　哲次
渡辺　陽一
武居　良太郎
津田　英直

Priority Data 03620884 07.11.1956 US

Title

(EN) INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS

(JA) 抗体の挿入可能な可変フラグメントおよびＮＫＧ２Ｄリガンドの改変Α１－Α２ドメイン

Abstract

(EN)

PROBLEM TO BE SOLVED: To provide, generally, polypeptides having specific antigen-binding properties of Fv domains.

SOLUTION: This application relates to production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified α1-α2 domains of NKG2D ligands.

SELECTED DRAWING: Figure 12

(JA)

【課題】本出願は、概して、Ｆｖドメインの特異的な抗原結合性特性を有するポリペプチドの提供に関する。
【解決手段】本出願は、Ｆｖドメインの特異的な抗原結合性特性を有するポリペプチド例えば抗体の挿入可能な可変フラグメント、およびＮＫＧ２Ｄリガンドの改変α１−α２ドメインの製造に関する。
【選択図】図１２

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
11	DNA or RNA fragments; Modified forms thereof
12	Genes encoding animal proteins

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
68	the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
395	Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12	Antivirals

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

Processing

National Phase Entries

Authority File

Settings

Feedback

Goto Application

1. JP2020114238 - INSERTABLE VARIABLE FRAGMENTS OF ANTIBODIES AND MODIFIED A1-A2 DOMAINS OF NKG2D LIGANDS

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants
2803	against the immunoglobulin superfamily
2818	against CD28 or CD152

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
30	characterized by aspects of specificity or valency
31	multispecific

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
60	characterized by non-natural combinations of immunoglobulin fragments
62	comprising only variable region components
622	Single chain antibody (scFv)

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
70	characterized by effect upon binding to a cell or to an antigen
73	Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
30	characterized by aspects of specificity or valency
31	multispecific