JPWO2019070013 細胞傷害性Ｔ細胞枯渇用組成物

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Application Number 2019547003

Application Date 04.10.2018

Publication Number WO2019070013

Publication Date 11.04.2019

Publication Kind A5

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Applicants 第一三共株式会社

Inventors 六笠　隆太
清澤　直樹
山田　真之亮

Agents 石橋　公樹
北野　範子
竹元　利泰
金原　玲子

Priority Data 2017194945 05.10.2017 JP

Title

(JA) 細胞傷害性Ｔ細胞枯渇用組成物

Abstract

(JA)

新規組成物を提供すること。下記（ｉ）乃至（ｉｉｉ）記載の性質を有する抗ＬＡＧ−３抗体又はその結合断片を含む、細胞傷害性Ｔ細胞枯渇用組成物：
（ｉ）イン・ビトロＡＤＣＣ活性を有する；
（ｉｉ）低フコース形態で、イン・ビボでＬＡＧ−３陽性細胞数を低減させる；及び、
（ｉｉｉ）ヒト活性化Ｔ細胞に結合する。

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
395	Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11	Drugs for disorders of the respiratory system

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11	Drugs for disorders of the respiratory system
06	Antiasthmatics

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29	Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)

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1. JPWO2019070013 - 細胞傷害性Ｔ細胞枯渇用組成物

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18	against material from animals or humans
28	against receptors, cell surface antigens or cell surface determinants

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor