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PROBLEM TO BE SOLVED: To provide novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria.
SOLUTION: There is provided a compound given by Formula (I) or a pharmaceutically acceptable salt thereof, wherein the dotted bond between A and B represents an optional bond so as to form a ring closed structure; Z represents -CH2-CH2- or >CH(CH3), A represents -SR, -OR or NHR, B represents -O-R', -NHR'', -SR''' or -OH; R' represents a specific substituent having carboxyl group: and R', R'' and R''' independently represent a specific substituent having carboxyl group or the like.
SELECTED DRAWING: None
COPYRIGHT: (C)2020,JPO&INPIT
【課題】ミトコンドリアでのATP産生を増加することを目的とする新規な細胞透過性サクシネート及びサクシネートの細胞透過性前駆体の提供。【解決手段】式(I)で表わされる化合物、又はその医薬として許容し得る塩。(式中、該A−B間の点線の結合は、閉環構造を形成するような任意の結合を示し、Zは、−CH2−CH2−、又は>CH(CH3);Aは、−SR、−OR、又はNHR;Bは、−O−R’、−NHR’’、−SR’’’、又は−OH;Rは、カルボキシル基を有する特定の置換基;R’、R’’、R’’’は、独立して、カルボキシル基を有する特定の置換基等である。)【選択図】なし