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1. JP2020100628 - NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS

Office
Japan
Application Number 2020018467
Application Date 06.02.2020
Publication Number 2020100628
Publication Date 02.07.2020
Publication Kind A
IPC
C07C 327/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
20Esters of monothiocarboxylic acids
28having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
C07C 327/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
20Esters of monothiocarboxylic acids
32having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
34with amino groups bound to the same hydrocarbon radicals
A61K 31/365
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
A61K 31/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K 31/265
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
265of carbonic, thiocarbonic or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
C07D 281/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
281Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
18Eight-membered rings
CPC
A61K 8/46
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
46containing sulfur
A61K 8/4926
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
4906with one nitrogen as the only hetero atom
4926having six membered rings
A61K 8/498
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
4973with oxygen as the only hetero atom
498having 6-membered rings or their condensed derivatives, e.g. coumarin
A61Q 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
C07C 327/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
20Esters of monothiocarboxylic acids
28having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
C07C 327/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
327Thiocarboxylic acids
20Esters of monothiocarboxylic acids
30having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
Applicants NEUROVIVE PHARMACEUTICAL AB
アブリバ エービー
Inventors ESKIL ELMER
エスキル エルメル
MAGNUS JOAKIM HANSSON
マグヌス ジョアキム ハンソン
KARL HENRIK JOHANNES EHINGER
カール ヘンリク ジョハンネス エヒンゲル
STEVEN MOSS
スティーブン モス
Agents 石川 徹
Priority Data PA201470190 08.04.2014 DK
Title
(EN) NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS
(JA) 新規な細胞透過性サクシネート化合物
Abstract
(EN)

PROBLEM TO BE SOLVED: To provide novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria.

SOLUTION: There is provided a compound given by Formula (I) or a pharmaceutically acceptable salt thereof, wherein the dotted bond between A and B represents an optional bond so as to form a ring closed structure; Z represents -CH2-CH2- or >CH(CH3), A represents -SR, -OR or NHR, B represents -O-R', -NHR'', -SR''' or -OH; R' represents a specific substituent having carboxyl group: and R', R'' and R''' independently represent a specific substituent having carboxyl group or the like.

SELECTED DRAWING: None

COPYRIGHT: (C)2020,JPO&INPIT


(JA)

【課題】ミトコンドリアでのATP産生を増加することを目的とする新規な細胞透過性サクシネート及びサクシネートの細胞透過性前駆体の提供。
【解決手段】式(I)で表わされる化合物、又はその医薬として許容し得る塩。

(式中、該A−B間の点線の結合は、閉環構造を形成するような任意の結合を示し、Zは、−CH−CH−、又は>CH(CH);Aは、−SR、−OR、又はNHR;Bは、−O−R’、−NHR’’、−SR’’’、又は−OH;Rは、カルボキシル基を有する特定の置換基;R’、R’’、R’’’は、独立して、カルボキシル基を有する特定の置換基等である。)
【選択図】なし