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1. JP2019536456 - 非小細胞肺癌患者由来のエクソソームRNA及び無細胞DNAを使用して血漿中の変異を検出するための方法と組成物

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Japan
Application Number 2019528833
Application Date 17.11.2017
Publication Number 2019536456
Publication Date 19.12.2019
Publication Kind A5
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Applicants エクソサム ダイアグノスティクス,インコーポレイティド
Inventors ヨーアン カール オロフ スコーグ
エレナ カステラノス-リザルドス
バシシュ タディゴトラ
ドミニク グリム
シュアン チャン
ウェイ ユー
Agents 青木 篤
三橋 真二
渡辺 陽一
中島 勝
武居 良太郎
津田 英直
Priority Data 62/428,059 30.11.2016 US
Title
(JA) 非小細胞肺癌患者由来のエクソソームRNA及び無細胞DNAを使用して血漿中の変異を検出するための方法と組成物
Abstract
(JA)

本発明は一般に、生物学的試料中の、上皮増殖因子受容体(EGFR)突然変異、例えばEGFR遺伝子中のT790M変異、L858R変異、1つ又は複数のエクソン19の挿入、及び/又は1つ又は複数のエクソン19の欠失などの1つ又は複数のバイオマーカーを検出して、例えば癌などの疾患の診断、予後予測、モニタリング、又は治療法選択を補助するための方法及びキットに関する。この方法及びキットは、肺癌、例えば非小細胞肺癌(NSCLC)の診断、予後予測、モニタリング、又は治療法選択を補助するのに有用である。