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1. JPWO2018151309 - 癌幹細胞の製造方法

Office
Japan
Application Number 2018568662
Application Date 20.02.2018
Publication Number WO2018151309
Publication Date 23.08.2018
Publication Kind A1
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Applicants 国立大学法人北海道大学
Inventors 田中 伸哉
安田 和則
グン 剣萍
津田 真寿美
黒川 孝幸
Agents 特許業務法人特許事務所サイクス
Priority Data 2017028833 20.02.2017 JP
Title
(JA) 癌幹細胞の製造方法
Abstract
(JA)

本発明は、癌細胞を含む生体細胞集団をゲル状物質の共存下で培養して癌幹細胞を含有する生体細胞集団を得ることを含み、ゲル状物質は、生体細胞集団に含まれる少なくとも一部の細胞におけるオステオポンチンの発現を誘起する材料である、癌幹細胞の製造方法に関する。さらに、本発明は、生体細胞集団に含まれる少なくとも一部の細胞におけるオステオポンチンの発現を誘起するゲル状物質を含む、癌細胞の癌幹細胞への転換誘導剤に関する。ここで、ゲル状物質は、例えば、ダブルネットワークゲル、PNaSSゲル、PCDMEゲル、PAゲル、PAMPSゲル、PDMAゲル、又はPAAcゲルからなる合成高分子ゲルである。高価な機器を必要とせず、培養コストは比較的安く、比較的短時間に癌幹細胞を調製できる手段及び方法を提供する。


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