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1. JP2019513414 - 組織修復のための臍帯血由来エキソソームの使用

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Japan
Application Number 2019501768
Application Date 24.03.2017
Publication Number 2019513414
Publication Date 30.05.2019
Grant Number 6952761
Grant Date 30.09.2021
Publication Kind B2
IPC
C12N 15/113
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 8/98
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
8Cosmetics or similar toiletry preparations
18characterised by the composition
96containing materials, or derivatives thereof, of undetermined constitution
98of animal origin
A61K 9/06
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor
A61K 9/08
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61K 9/107
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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10Dispersions; Emulsions
107Emulsions
A61K 9/12
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
12Aerosols; Foams
CPC
A61K 31/7105
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 35/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
51Umbilical cord; Umbilical cord blood; Umbilical stem cells
C12N 15/113
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
C12N 2310/141
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2310Structure or type of the nucleic acid
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14interfering N.A.
141MicroRNAs, miRNAs
C12N 2320/32
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2320Applications; Uses
30Special therapeutic applications
32Special delivery means, e.g. tissue-specific
C12N 2330/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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2330Production
10naturally occurring
FI
A61K 31/7105
A61K 35/51
A61K 47/02
A61K 47/42
A61K 8/98
A61K 9/06
F-term
4B065AA92X
4B065AA94X
4B065AA94Y
4B065AB01
4B065BA01
4B065BD15
Applicants ステムラボ，エスエイ
バイオキャント－アソシアカオ　デ　トランスフェレンシア　デ　テクノロジー
Inventors フェレーラ，リノ　ダ　シルヴァ
コレーア，ジョアナ，リタ，シモエズ
カルドソ，レナート，マヌエル，ソアレス
アントゥネス，マリア，ヘレナ，ヘンリクェズ
Agents ▲吉▼川　俊雄
市川　寛奈
Priority Data 62/313,002 24.03.2016 US
62/336,907 16.05.2016 US
Title
(JA) 組織修復のための臍帯血由来エキソソームの使用
Abstract
(JA)

本発明は、創傷治癒を必要とする患者において、創傷治癒を促進する方法であって、該患者の創傷を、臍帯血単核細胞（ＵＣＢＭＮＣ）によって分泌されたエキソソームと接触させ、それにより該患者における創傷治癒を促進することを含む方法を提供する。また、本出願は、創傷治癒を必要とする患者において、創傷治癒を促進する方法であって、前記患者の創傷を、１つ又は複数のｍｉＲＮＡ及び薬学上許容可能な担体を含む組成物と接触させ、それにより前記患者における創傷治癒を促進する方法も提供する。
【選択図】なし
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