JPWO2018097307 抗原結合ドメインおよび運搬部分を含むポリペプチド

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Application Number 2018553013

Application Date 28.11.2017

Publication Number WO2018097307

Publication Date 31.05.2018

Grant Number 7001615

Grant Date 28.12.2021

Publication Kind B1

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Applicants 中外製薬株式会社

Inventors 井川　智之
石川　広幸
廣庭　奈緒香

Agents 春名　雅夫
清水　初志
山口　裕孝
刑部　俊
井上　隆一
佐藤　利光
新見　浩一
小林　智彦
小寺　秀紀
大関　雅人
川本　和弥

Priority Data 2016229794 28.11.2016 JP

Title

(JA) 抗原結合ドメインおよび運搬部分を含むポリペプチド

Abstract

(JA)

本発明は、抗原結合ドメインと、抗原結合ドメインの抗原結合活性を抑制する抑制ドメインを有する運搬部分とを含み、かつ単独で存在する抗原結合ドメインより長い半減期を有するポリペプチド、当該ポリペプチドの製造方法およびスクリーニング方法、当該ポリペプチドを含む医薬組成物、特定のVL／VH／VHHと会合することで抗原結合活性が抑制される単ドメイン抗体の製造方法及びスクリーニング方法、ならびに特定のVL／VH／VHHと会合することで抗原結合活性が抑制される単ドメイン抗体を含む融合ポリペプチドのライブラリに関する。

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
19	Hybrid peptides

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
395	Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid
64	Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid
65	Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
68	the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

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1. JPWO2018097307 - 抗原結合ドメインおよび運搬部分を含むポリペプチド

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
11	DNA or RNA fragments; Modified forms thereof
12	Genes encoding animal proteins
13	Immunoglobulins

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70	involving virus or bacteriophage

C	CHEMISTRY; METALLURGY
40	COMBINATORIAL TECHNOLOGY
B	COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30	Methods of screening libraries
04	by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15	Medicinal preparations

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37	Drugs for immunological or allergic disorders
02	Immunomodulators
06	Immunosuppressants, e.g. drugs for graft rejection