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1. JP2018534333 - 異所性脂肪蓄積治療用Ａ３アデノシン受容体リガンド

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Japan
Application Number 2018526535
Application Date 22.11.2016
Publication Number 2018534333
Publication Date 22.11.2018
Grant Number 6980655
Grant Date 19.11.2021
Publication Kind B2
IPC
A61K 31/7076
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 31/7076
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61K 9/0053
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
Applicants キャン－ファイト　バイオファーマ　リミテッド
Inventors フィッシュマン，プニナ
コーエン，シラ
Agents 特許業務法人北青山インターナショナル
Priority Data 242723 23.11.2015 IL
Title
(JA) 異所性脂肪蓄積治療用Ａ３アデノシン受容体リガンド
Abstract
(JA)

本開示は、特に脂肪肝における、異所性脂肪蓄積を低減するＡ３ＡＲリガンドに関する。また、本開示によれば、このような脂肪蓄積を低減する医薬組成物の製造用Ａ３ＡＲリガンドの使用、このリガンドを使用した脂肪蓄積に伴う症状を治療する方法、及び、異所性脂肪蓄積に関連する症状を治療するための、前記リガンドを含む医薬組成物と、当該医薬組成物の使用のための指示書、とを具えるキット、が提供されている。一の実施例において、本開示は、脂肪肝、特に、非アルコール性脂肪性肝臓疾患（ＮＡＦＬＤ）の治療用の、２−クロロ−Ｎ６−（３−ヨードベンジル）−アデノシン−５’−Ｎ−メチルウロナミド（Ｃｌ−ＩＢ−ＭＥＣＡ、ＣＦ１０２）の使用を提供している。
【選択図】なし
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