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1. JP2017141268 - PREVENTIVE AND/OR THERAPEUTIC AGENT OF PERIPHERAL NEUROPATHIC PAIN CAUSED BY ANTI-CANCER AGENT

Office
Japan
Application Number 2017071200
Application Date 31.03.2017
Publication Number 2017141268
Publication Date 17.08.2017
Grant Number 6279788
Grant Date 26.01.2018
Publication Kind B2
IPC
A61K 38/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
A61K 31/475
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
475having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
A61K 31/69
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
69Boron compounds
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 31/337
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
337having four-membered rings, e.g. taxol
C07K 14/7455
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
745Blood coagulation or fibrinolysis factors
7455Thrombomodulin
A61K 38/366
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
36Blood coagulation or fibrinolysis factors
366Thrombomodulin
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
Applicants KINKI UNIV
学校法人近畿大学
ASAHI KASEI PHARMA KK
旭化成ファーマ株式会社
Inventors KAWABATA ATSUSHI
川畑 篤史
SUZUKI HIDEAKI
鈴木 秀明
Agents 特許業務法人特許事務所サイクス
Priority Data 2012125316 31.05.2012 JP
Title
(EN) PREVENTIVE AND/OR THERAPEUTIC AGENT OF PERIPHERAL NEUROPATHIC PAIN CAUSED BY ANTI-CANCER AGENT
(JA) 抗癌剤に起因する末梢性神経障害性疼痛の予防及び/又は治療剤
Abstract
(EN)

PROBLEM TO BE SOLVED: To provide a medical drug effective for preventing and/or treating peripheral neuropathic pain such as allodynia caused by therapy by an anti-cancer agent.

SOLUTION: A medical drug containing thrombomodulin as an active ingredient is for preventing and/or treating peripheral neuropathic pain caused by an anti-cancer agent such as a taxane pharmaceutical preparation, a platinum pharmaceutical preparation, a vinca alkaloid based medicine, and bortezomib. It is preferable that the medical drug be intravenously administered or subcutaneously administered in combination with the anti-cancer agent. It is preferable that the thrombomodulin be acquired by transformed cell, be soluble thrombomodulin, and be human thrombomodulin.

SELECTED DRAWING: None

COPYRIGHT: (C)2017,JPO&INPIT


(JA)

【課題】抗癌剤による治療に起因する異痛症などの末梢性神経障害性疼痛の予防及び/又は治療に有効な医薬の提供。
【解決手段】タキサン製剤、白金製剤、ビンカアルカロイド系薬剤、ボルテゾミブ等の抗癌剤に起因する末梢性神経障害性疼痛の予防及び/又は治療のための、トロンボモジュリンを有効成分として含有する医薬。該医薬は、上記抗癌剤と組み合わせ、静脈内投与又は皮下投与されることが好ましい。該トロンボモジュリンが、形質転換細胞により取得されるものであり、可溶性トロンボジュリンであり、ヒトトロンボジュリンであることが好ましい。
【選択図】なし