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1. JP2017099392 - NOVEL ANTI-cMET ANTIBODY

Office
Japan
Application Number 2017000641
Application Date 05.01.2017
Publication Number 2017099392
Publication Date 08.06.2017
Grant Number 6309657
Grant Date 23.03.2018
Publication Kind B2
IPC
C12N 15/09
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C12N 1/15
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
14Fungi ; Culture media therefor
15modified by introduction of foreign genetic material
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/2863
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2863against receptors for growth factors, growth regulators
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/53
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
53Hinge
C07K 2317/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
Applicants PIERRE FABRE MEDICAMENT
ピエール、ファーブル、メディカマン
Inventors LILIANE GOETSCH
リリアーヌ、ゲッチ
THIERRY WURCH
ティエリー、ウルチ
CEDRIC BES
セドリック、ベス
Agents 永井 浩之
中村 行孝
佐藤 泰和
朝倉 悟
反町 洋
松山 祐子
Priority Data PCT/IB2008/055663 02.12.2008 IB
61/184,502 05.06.2009 US
Title
(EN) NOVEL ANTI-cMET ANTIBODY
(JA) 新規な抗cMET抗体
Abstract
(EN)

PROBLEM TO BE SOLVED: To provide an antibody which can specifically bind to a human c-Met receptor and/or specifically inhibit the tyrosine kinase activity of the receptor and has an improved antagonistic activity, and a composition comprising an antibody antagonist to c-Met.

SOLUTION: A monoclonal antibody which can inhibit c-Met dimerization, or a divalent functional fragment or derivative thereof comprises a heavy chain comprising CDR-H1, CDR-H2 and CDR-H3 which have a particular amino acid sequence, a light chain comprising CDR-L1, CDR-L2 and CDR-L3 which have a particular amino acid sequence, and further a hinge region comprising a particular amino acid sequence.

SELECTED DRAWING: None

COPYRIGHT: (C)2017,JPO&INPIT


(JA)

【課題】ヒトc−Met受容体に特異的に結合することができおよび/または前記受容体のチロシンキナーゼ活性を特異的に阻害することができ、改良された拮抗活性を有する抗体、およびc−Metに対する抗体拮抗薬を含んでなる組成物の提供。
【解決手段】c−Met二量体化を阻害することができるモノクローナル抗体またはその二価の機能性断片もしくは誘導体であって、特定のアミノ酸配列を有するCDR−H1、CDR−H2およびCDR−H3を含む重鎖と、特定のアミノ酸配列を有するCDR−L1、CDR−L2およびCDR−L3を含む軽鎖とを含んでなり、更に特定のアミノ酸配列を含むヒンジ領域をも含んでなる、モノクローナル抗体またはその二価の機能性断片もしくは誘導体。
【選択図】なし


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