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1. JP2017524341 - ハイブリッドtRNA/プレmiRNA分子および使用方法

Office
Japan
Application Number 2016569679
Application Date 21.05.2015
Publication Number 2017524341
Publication Date 31.08.2017
Publication Kind A5
IPC
C12N 15/113
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 9/127
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 9/51
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48Preparations in capsules, e.g. of gelatin, of chocolate
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A61K 31/7105
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7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 35/76
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35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
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A61P 35/00
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35Antineoplastic agents
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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111General methods applicable to biologically active non-coding nucleic acids
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2310Structure or type of the nucleic acid
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30Chemical structure
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351Conjugate
3519Fusion with another nucleic acid
Applicants ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア
Inventors ユ エイミング
ワン ウェイペン
チェン チウシャ
リ メイメイ
Agents 清水 初志
春名 雅夫
山口 裕孝
刑部 俊
井上 隆一
佐藤 利光
新見 浩一
小林 智彦
小寺 秀紀
大関 雅人
五十嵐 義弘
川本 和弥
Priority Data 62/003,806 28.05.2014 US
Title
(JA) ハイブリッドtRNA/プレmiRNA分子および使用方法
Abstract
(JA)

tRNA/プレマイクロRNAおよびtRNA/shRNAハイブリッド分子ならびに作製方法および使用方法が提供される。従って、一局面では、プレマイクロRNA(プレmiRNA)またはショートヘアピンRNA(shRNA)に機能的に連結されたtRNAを含むポリヌクレオチドが提供される。様々な態様において、tRNAはメチオニルtRNAである。様々な態様において、プレmiRNA(またはshRNA)は、プレmiRNA-1291、プレmiRNA-34a、プレmiRNA-125b、プレmiRNA-124、プレmiRNA-27b、およびプレmiRNA-22より選択される。