JP2017513829 新規な細胞透過性サクシネート化合物

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Application Number 2016561677

Application Date 08.04.2015

Publication Number 2017513829

Publication Date 01.06.2017

Grant Number 7082861

Grant Date 01.06.2022

Publication Kind B1

IPC

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Applicants アブリバ　エービー

Inventors エスキル　エルメル
マグヌス　ジョアキム　ハンソン
カール　ヘンリク　ジョハンネス　エヒンゲル
スティーブン　モス

Agents 石川　徹

Priority Data PA201470190 08.04.2014 DK

Title

(JA) 新規な細胞透過性サクシネート化合物

Abstract

(JA)

本発明は、ミトコンドリアでのATP産生を増加することを目的とする新規な細胞透過性サクシネート及びサクシネートの細胞透過性前駆体を提供する。真核細胞内で産生され利用されるATPの主要部分は、クレブス回路による高エネルギー電子の提供先のプロセスであるミトコンドリアの酸化的リン酸化に由来する。クレブス回路中間体の全てが細胞膜易透過性であるわけではなく、サクシネートはその１種である。新規な細胞透過性サクシネートを提供することにより、細胞膜の通過を可能とすることが想定され、従って、該細胞透過性サクシネートは、ミトコンドリアのATP産出を増強するために使用可能である。
【選択図】なし

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
327	Thiocarboxylic acids
20	Esters of monothiocarboxylic acids
30	having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
21	Esters, e.g. nitroglycerine, selenocyanates
265	of carbonic, thiocarbonic or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
335	having oxygen as the only ring hetero atom, e.g. fungichromin
365	Lactones

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9	Drugs for disorders of the cardiovascular system

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1. JP2017513829 - 新規な細胞透過性サクシネート化合物

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q	SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19	Preparations for care of the skin

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02	TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
A	TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50	in human health protection, e.g. against extreme weather
30	Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
211	Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04	with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68	having one double bond between ring members or between a ring member and a non-ring member
72	with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
74	Oxygen atoms
76	attached in position 2 or 6

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
309	Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
16	having one double bond between ring members or between a ring member and a non-ring member
28	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
30	Oxygen atoms, e.g. delta-lactones