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1. JP2015536981 - 三環式化合物ならびにその製造および使用方法

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Japan
Application Number 2015541850
Application Date 05.11.2013
Publication Number 2015536981
Publication Date 24.12.2015
Publication Kind A
IPC
C07D 311/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
94condensed with rings other than six-membered or with ring systems containing such rings
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/4025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025not condensed and containing further heterocyclic rings, e.g. cromakalim
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
C07D 311/78
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
C07D 311/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
94condensed with rings other than six-membered
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants ザフゲン，インコーポレイテッド
Inventors パリン，トーマス，デイビッド
クランプ，スーザン，メアリー
ザーラー，ロバート
Agents 新樹グローバル・アイピー特許業務法人
Priority Data 61/722,455 05.11.2012 US
Title
(JA) 三環式化合物ならびにその製造および使用方法
Abstract
(JA)

以下の式で表される三環式化合物ならびにその医薬的に許容される塩、立体異性体、エステルおよびプロドラッグ。


（式中、Ｂは、３〜５員飽和複素環式または飽和炭素環式環等；Ｄは、５〜６員飽和複素環式または飽和炭素環式環等；Ｘは、＋−Ｃ（ＲＤ１ＲＤ２）−＊、＋−Ｗ１−＊等；Ｙは、結合、＊−ＣＨ２−＃、＊−Ｏ−＃等；Ｗ１は、ＯまたはＮ（ＲＮ１）；ＲＢ１およびＲＢ２は、各々、水素、フッ素、ヒドロキシル、シアノ等；ＲＥ１およびＲＥ２は、各々、水素、ハロゲン、シアノ、Ｃ１−３アルキル等；Ａは、フェニルおよび５〜６員ヘテロアリールから選択される環等；ＲＡ１は、それぞれ、水素、ヒドロキシル、シアノ、ハロゲン、Ｃ１−４アルキル等；ｎは、１または２；ＲＡ２は、水素、ヘテロシクリル、ヘテロシクリルオキシ等で表される。）
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