JP2015512910 ヒトＰＤ１のＢＣループに由来する免疫調節性環状化合物

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Japan

Application Number 2015502472

Application Date 28.03.2013

Publication Number 2015512910

Publication Date 30.04.2015

Publication Kind A

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Applicants オーリジーン　ディスカバリー　テクノロジーズ　リミテッド

Inventors サシクマル，ポタイル，ゴーヴィンダン，ナイール
ラーマチャンドラ，ムラリドハラ

Agents 岸本　達人
山下　昭彦
山本　典輝

Priority Data 1213/CHE/2012 29.03.2012 IN

Title

(JA) ヒトＰＤ１のＢＣループに由来する免疫調節性環状化合物

Abstract

(JA)

本発明は、プログラム細胞死１（ＰＤ１）のシグナル伝達経路を阻害することが可能な治療剤としての新規の環状化合物に関する。本発明は当該治療剤の誘導体にも関する。本発明は、ＰＤ‐１、ＰＤ−Ｌ１またはＰＤ−Ｌ２によって生じる免疫抑制シグナルの阻害作用からなる免疫増強作用によって疾患を処置するための当該治療剤及び誘導体の使用、及び、それらを用いた治療法も包含する。

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
7	Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04	Linear peptides containing only normal peptide links
06	having 5 to 11 amino acids

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents
02	specific for leukemia

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1. JP2015512910 - ヒトＰＤ１のＢＣループに由来する免疫調節性環状化合物

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
7	Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50	Cyclic peptides containing at least one abnormal peptide link
54	with at least one abnormal peptide link in the ring
56	the cyclisation not occurring through 2,4-diamino-butanoic acid

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides
16	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17	from animals; from humans
177	Receptors; Cell surface antigens; Cell surface determinants
1774	Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
46	from vertebrates
47	from mammals
4701	not used
4747	Apoptosis related proteins

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
705	Receptors; Cell surface antigens; Cell surface determinants
70503	Immunoglobulin superfamily
70521	CD28, CD152