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1. JP2015028024 - NEBULIZABLE COMPOSITIONS OF QUATERNARY AMMONIUM MUSCARINIC RECEPTOR ANTAGONISTS

Office Japan
Application Number 2014161093
Application Date 07.08.2014
Publication Number 2015028024
Publication Date 12.02.2015
Publication Kind A
IPC
A61K 9/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
12Aerosols; Foams
A61K 9/72
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
72for smoking or inhaling
A61K 31/46
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
468-Azabicyclo octane; Derivatives thereof, e.g. atropine, cocaine
A61P 11/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
08Bronchodilators
CPC
A61K 9/0078
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
0078for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
A61K 9/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61K 31/439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
439the ring forming part of a bridged ring system, e.g. quinuclidine
A61K 31/4745
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4738ortho- or peri-condensed with heterocyclic ring systems
4745condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
A61K 31/573
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573substituted in position 21, e.g. cortisone, dexamethasone, prednisone ; or aldosterone
A61P 11/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
08Bronchodilators
Applicants DEY LP
デイ・リミテッド・パートナーシップ
Inventors CHAUDRY IMTIAZ A
イムティアズ・エイ・チョードリー
Agents 山田 卓二
青山 葆
松谷 道子
Priority Data 60/803,309 26.05.2006 US
Title
(EN) NEBULIZABLE COMPOSITIONS OF QUATERNARY AMMONIUM MUSCARINIC RECEPTOR ANTAGONISTS
(JA) 4級アンモニウムムスカリン受容体アンタゴニストの噴霧可能組成物
Abstract
(EN)

PROBLEM TO BE SOLVED: To provide a kit for treatment, prevention, or amelioration of one or more symptoms of bronchoconstrictive disorders.

SOLUTION: A kit comprises (i) a nebulizer and (ii) a nebulizable composition for the treatment or amelioration or one or more symptoms of disorders associated with bronchoconstriction, which composition comprises: (a) a quaternary ammonium muscarinic receptor antagonist in a concentration based on the ammonium of between about 0.0005% and about 5% by weight; (b) formoterol free base at a concentration of about 5 μg/mL to about 2 mg/mL; (c) a pharmacologically acceptable fluid; and (d) a pharmacologically acceptable preservative, wherein the pH of the preparation is adjusted between about 2.0 to about 4.5 with an acid, the quaternary ammonium muscarinic receptor antagonist is dissolved in the fluid, and the composition optionally includes pharmacologically acceptable complexing agent, stabilizer, a pharmacologically acceptable cosolvent, or other pharmacologically acceptable adjuvants and additives.

COPYRIGHT: (C)2015,JPO&INPIT

(JA)

【課題】気管支収縮性障害の処置、予防、または1種以上の症状の改善用キットの提供。
【解決手段】(i)ネブライザー、(ii)気管支収縮に関連する障害の処置または1種以上の症状の改善用噴霧可能組成物であって、(a)アンモニウムに基づいて0.0005%〜5重量%の濃度の4級アンモニウムムスカリン受容体アンタゴニスト、(b)5μg/mL〜2mg/mLの濃度のフォルモテロール遊離塩基、(c)薬理学的に許容される流体、および、(d)薬理学的に許容される防腐剤を含み、ここで、該組成物のpHが酸で2.0〜4.5に調節されており、そして該4級アンモニウムムスカリン受容体アンタゴニストが該流体に溶解しており、そして該組成物が所望により薬理学的に許容される錯化剤、安定化剤、薬理学的に許容される共溶媒、または他の薬理学的に許容されるアジュバントおよび添加剤を含む、組成物などを含むキット。
【選択図】なし