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1. JP2014501719 - キラルスピロ-ピリジルアミドフォスフィン配位子化合物、その合成方法及びその利用

Office Japan
Application Number 2013539127
Application Date 18.11.2011
Publication Number 2014501719
Publication Date 23.01.2014
Grant Number 5923105
Grant Date 22.04.2016
Publication Kind B2
IPC
C07F 9/58
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
553having one nitrogen atom as the only ring hetero atom
576Six-membered rings
58Pyridine rings
B01J 31/24
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31Catalysts comprising hydrides, coordination complexes or organic compounds
16containing coordination complexes
24Phosphines
C07B 41/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
41Formation or introduction of functional groups containing oxygen
02of hydroxy or O-metal groups
C07B 53/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
53Asymmetric syntheses
C07C 29/145
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
132by reduction of an oxygen-containing functional group
136of C=O containing groups, e.g. -COOH
143of ketones
145with hydrogen or hydrogen-containing gases
C07C 31/135
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
31Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
13Monohydroxylic alcohols containing saturated rings
133monocyclic
135with five- or six-membered rings; Naphthenic alcohols
CPC
B01J 31/249
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31Catalysts comprising hydrides, coordination complexes or organic compounds
16containing coordination complexes
24Phosphines ; , i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
2404Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
2442comprising condensed ring systems
249Spiro-condensed ring systems
B01J 31/189
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31Catalysts comprising hydrides, coordination complexes or organic compounds
16containing coordination complexes
18containing nitrogen, phosphorus, arsenic or antimony ; as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
189containing both nitrogen and phosphorus as complexing atoms, including e.g. phosphino moieties, in one at least bidentate or bridging ligand
B01J 2231/643
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2231Catalytic reactions performed with catalysts classified in B01J31/00
60Reduction reactions, e.g. hydrogenation
64Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
641Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
643of R2C=O or R2C=NR (R= C, H)
B01J 2531/827
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2531Additional information regarding catalytic systems classified in B01J31/00
80Complexes comprising metals of Group VIII as the central metal
82Metals of the platinum group
827Iridium
C07B 41/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
41Formation or introduction of functional groups containing oxygen
02of hydroxy or O-metal groups
C07B 53/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
53Asymmetric syntheses
Applicants ジェジャン ジウジョウ ファーマ サイエンス アンド テクノロジー カンパニー リミテッド
Inventors 周 其林
謝 建▲華▼
▲劉▼ ▲暁▼▲艶▼
謝 ▲剣▼波
王 立新
Agents 西川 惠清
水尻 勝久
竹尾 由重
坂口 武
北出 英敏
仲石 晴樹
時岡 恭平
木村 豊
Title
(JA) キラルスピロ-ピリジルアミドフォスフィン配位子化合物、その合成方法及びその利用
Abstract
(JA)

【解決手段】本発明は、キラルスピロ−ピリジルアミドフォスフィン配位子化合物、その合成方法及びその利用に関する。キラルスピロ−ピリジルアミドフォスフィン化合物は、構造式(I)を有する化合物、又はそのラセミ化合物、又はその光学異性体、又は触媒的に許容可能なその塩であり、その構造中に、キラルスピロ−ジハイドロ−インデン骨格を有することが主な特徴である。キラルスピロ−ピリジルアミドフォスフィン化合物は、キラル出発物質として、スピロ骨格を有する光学活性のある7−ジアリル/アルキルフォスフィノ−7′−アミノ−1,1′−スピロ−ジハイドロ−インデン、又は置換7−ジアリル/アルキルフォスフィノ−7′−アミノ−1,1′−スピロ−ジハイドロ−インデンにより合成され得る。キラルスピロ−ピリジルアミドフォスフィン化合物は、イリジウム触媒によるカルボニル化合物の不斉水素化において、キラル触媒として用いられ、その反応活性は非常に高く、触媒量は0.0001mol%であり、この反応のエナンチオ選択性は99.9%eeになる。
【化1】