JP2013513609 光力学的療法のためのヒト血清アルブミンをベースにしたナノ粒子キャリアシステム

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Application Number 2012543221

Application Date 08.12.2010

Publication Number 2013513609

Publication Date 22.04.2013

Grant Number 5972171

Grant Date 22.07.2016

Publication Kind B2

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Applicants バイオリテック　ファーマ　マーケティング　リミテッド

Inventors ランガー、クラウス
ヴァッカー、マティアス
レーダー、ベアーテ
プルース、アンネグレット
アルブレヒト、フォルカー
グレーフェ、スザンナ
ヴィーエ、アルノ
フォン　ブリーセン、ハーゲン
ワグナー、シルビア

Agents 木村　満
毛受　隆典
森川　泰司
雨宮　康仁
桜田　圭

Priority Data 12941350 08.11.2010 US
61/285,902 11.12.2009 US

Title

(JA) 光力学的療法のためのヒト血清アルブミンをベースにしたナノ粒子キャリアシステム

Abstract

(JA)

保存において安定な組成物と、疎水性の光増感剤、ヒト血清アルブミン（ＨＳＡ）および安定化剤を含む光力学的療法のためのナノ粒子製剤系薬剤の製造方法とを提供する。これらのナノ粒子製剤は、非経口投与に関して光増感剤（ＰＳ）の治療上の有効量を提供する。特にテトラピロール誘導体は光増感剤として用いられ、その有効性と安全性とが上記ナノ粒子製剤によって高められる。また、無菌条件下でのＨＳＡ系ナノ粒子の調製方法が提供される。本発明に係る好ましい１つの実施の形態では、テモポルフィン、疎水性の光増感剤が非経口投与のためのナノ粒子として製剤化される。当該製剤は、過形成や腫瘍性疾患、炎症性疾患を治療するため、さらに具体的には、腫瘍細胞を標的とするために有用である。
【選択図】図６

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40	having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
409	having four such rings, e.g. porphine derivatives, bilirubin, biliverdine

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41	Medicinal preparations obtained by treating materials with wave energy or particle radiation

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30	Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42	Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13	Drugs for disorders of the urinary system

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17	Drugs for dermatological disorders

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1. JP2013513609 - 光力学的療法のためのヒト血清アルブミンをベースにしたナノ粒子キャリアシステム

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
48	Preparations in capsules, e.g. of gelatin, of chocolate
50	Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51	Nanocapsules; Nanoparticles;
5107	Excipients; Inactive ingredients
513	Organic macromolecular compounds; Dendrimers
5169	Proteins, e.g. albumin, gelatin

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41	Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057	Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
0071	PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
48	Preparations in capsules, e.g. of gelatin, of chocolate
50	Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51	Nanocapsules; Nanoparticles;
5107	Excipients; Inactive ingredients
513	Organic macromolecular compounds; Dendrimers
5169	Proteins, e.g. albumin, gelatin

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41	Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057	Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
0071	PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines