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1. JP2008517613 - 真性赤血球増加症に関与するJAK2の変異の識別方法

Office
Japan
Application Number 2007538421
Application Date 26.10.2005
Publication Number 2008517613
Publication Date 29.05.2008
Grant Number 5090171
Grant Date 21.09.2012
Publication Kind B2
IPC
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Applicants アシスタンス ピュブリック-オピト ドゥ パリ
アンスティテュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル(インセルム)
アンスティテュ ギュスターブ-ルシ
ユニヴェルシテ ドゥ ヴェルサイユ-サン クァンタン アン イヴェリーヌ
ユニヴェルシテ パリ-シュド
Inventors ヴァンシャンケ、ウィリアム
ウーゴ、ヴァレリー
ジャム、クローエ
レ クェディック、ジャン-ピエール
カザデバル、ニコル
Agents 太田 恵一
Priority Data 0411480 27.10.2004 FR
Title
(JA) 真性赤血球増加症に関与するJAK2の変異の識別方法
Abstract
(JA)

本発明は、真性赤血球増加症の原因となっている、JAK2チロシンキナーゼタンパク質のV617F変異体に関するものである。また、本発明は、赤血球増加症と血小板増加症を骨髄増殖症候群に関連付けることを可能にする、赤血球増加症および血小板増加症の一次診断方法、すなわち、赤血球増加症と血小板増加症を新たな疾病群に再分類することを可能にする、骨髄増殖症候群におけるJAK2 V617F変異体の検出にも関するものであり、そして、特異的阻害剤とsiRNAの識別にも関するものである。