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1. JP2008001710 - ANALOGUES OF GLP-1

Office Japan
Application Number 2007191581
Application Date 24.07.2007
Publication Number 2008001710
Publication Date 10.01.2008
Publication Kind A
IPC
C07K 14/605
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
605Glucagons
A61K 38/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
26Glucagons
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
Applicants SOC DE CONSEILS DE RECHERCHES & D'APPLICATIONS SCIENTIFIQUES SAS
ソシエテ ド コンセイユ ド ルシェルシェ エ ダアップリカーション シャンティフィック (エス.セー.エール.アー.エス.)
Inventors DONG ZHENG XIN
ドン,ツェン・シン
Agents 社本 一夫
小野 新次郎
小林 泰
千葉 昭男
富田 博行
中濱 明子
Priority Data 09/206,601 07.12.1998 US
60/111,255 07.12.1998 US
Title
(EN) ANALOGUES OF GLP-1
(JA) GLP-1の類似体
Abstract
(EN)

PROBLEM TO BE SOLVED: To provide GLP-1 analogues which have higher activities than that of native glucagon-like peptide-1 (GLP-1) or are metabolically stable.

SOLUTION: Glucagon-like peptide-1 analogues and pharmaceutically acceptable salts thereof are provided, wherein the peptide analogues consist mainly of specific about 36 to 39C sequence amino acids or analogues thereof, contain alkyl or acyl derivatives in stead of amino acids in a partial chain, and increase metabolic stability.

COPYRIGHT: (C)2008,JPO&INPIT

(JA)

【課題】ネーティブなグルカゴン様ペプチド−1(GLP−1)より活性が高い、または代謝的により安定であるGLP−1類似体を提供する。
【解決手段】グルカゴン様ペプチド−1のペプチド類似体、及びその製剤的に許容される塩であって、該ペプチド類似体は、主に約36〜39程度の特定の配列のアミノ酸またはその類縁体から構成されるが、一部鎖内にアミノ酸の代わりにアルキルまたはアシル誘導体を含み、代謝安定性を増している。
【選択図】なし