JP2007105055 METHOD FOR PRODUCING PURINE NUCLEOSIDE BY FERMENTATION METHOD

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Application Number 2007018263

Application Date 29.01.2007

Publication Number 2007105055

Publication Date 26.04.2007

Grant Number 4375405

Grant Date 18.09.2009

Publication Kind B2

IPC

Applicants AJINOMOTO CO INC
味の素株式会社

Inventors MATSUI YUTAKA
松井　裕
KAWASAKI HISASHI
川崎　寿
SHIMAOKA MEGUMI
島岡　恵
TAKENAKA YASUHIRO
竹中　康浩
KURAHASHI OSAMU
倉橋　修

Agents 川口　嘉之
松倉　秀実
遠山　勉

Priority Data 1997194603 18.07.1997 JP

Title

(EN) METHOD FOR PRODUCING PURINE NUCLEOSIDE BY FERMENTATION METHOD

(JA) 発酵法によるプリンヌクレオシドの製造法

Abstract

(EN)

PROBLEM TO BE SOLVED: To provide a method for producing a purine nucleoside by a fermentation method.

SOLUTION: Bacteria, belonging to the genus Escherichia of microorganisms in which feedback inhibition of phosphoribosyl pyrophosphate amidotransferase and/or phosphoribosyl pyrophosphate synthetase is removed, and having purine nucleoside-producing abilities, are cultured in a medium to allow the purine nucleoside to be formed and accumulated, and the purine nucleoside is collected.

(JA)

【課題】発酵法によるプリヌクレオシドの優れた製造法を提供する。
【解決手段】ホスホリボシルピロリン酸アミドトランスフェラーゼ及び／またはホスホリボシルピロリン酸シンセターゼのフィードバック阻害が解除された細菌である、プリンヌクレオシド生産能を有するエシェリヒア属細菌を培地に培養し、プリンヌクレオシドを生成蓄積せしめ、プリンヌクレオシドを回収する。
【選択図】なし

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P	FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19	Preparation of compounds containing saccharide radicals
26	Preparation of nitrogen-containing carbohydrates
28	N-glycosides
30	Nucleotides
32	having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same-ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P	FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19	Preparation of compounds containing saccharide radicals
26	Preparation of nitrogen-containing carbohydrates
28	N-glycosides
38	Nucleosides
40	having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P	FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19	Preparation of compounds containing saccharide radicals
26	Preparation of nitrogen-containing carbohydrates
28	N-glycosides
30	Nucleotides
32	having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same-ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology

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