(EN) PROBLEM TO BE SOLVED: To provide a GLP-1 analogue which is used for treating a mammal with a defective absorption syndrome such as diabetes, obesity, kidney dysfunction, or hypoglycemia and is more active or metabolically stable than a native glucagon-like peptide-1 (7-36) amide (GLP-1).
SOLUTION: A peptide analogue of a glucagon-like peptide-1 consisting of a specific amino acid sequence is provided, and so is a medicine composition which contains an effective amount of a pharmaceutically allowable salt of the peptide analogue and a pharmaceutically allowable carrier or diluent.
COPYRIGHT: (C)2006,JPO&NCIPI
【課題】糖尿病、肥満、腎不全、低血糖症などの吸収不全症候群の哺乳動物を治療するための、ネーティブなグルカゴン様ペプチド−１（７−３６）アミド（ＧＬＰ−１）より活性であるか又はより代謝的に安定であるＧＬＰ−１類似体の提供。
【解決手段】特定なアミノ酸配列からなるグルカゴン様ペプチド−１のペプチド類似体、及びその製剤的に許容される塩の有効量と製剤的に許容される担体まはた希釈剤を含んでなる医薬組成物の提供。
【選択図】なし