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1. JP2006151988 - ANALOGUE OF GLP-1

Office Japan
Application Number 2005374822
Application Date 27.12.2005
Publication Number 2006151988
Publication Date 15.06.2006
Grant Number 4386887
Grant Date 09.10.2009
Publication Kind B2
IPC
C07K 14/605
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
605Glucagons
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
Applicants SOC DE CONSEILS DE RECHERCHES & D'APPLICATIONS SCIENTIFIQUES SAS
ソシエテ ド コンセイユ ド ルシェルシェ エ ダアップリカーション シャンティフィック (エス.セー.エール.アー.エス.)
Inventors DONG ZHENG XIN
ドン,ツェン・シン
Agents 社本 一夫
今井 庄亮
増井 忠弐
小林 泰
富田 博行
江尻 ひろ子
Priority Data 09/206,601 07.12.1998 US
60/111,255 07.12.1998 US
Title
(EN) ANALOGUE OF GLP-1
(JA) GLP-1の類似体
Abstract
(EN)

PROBLEM TO BE SOLVED: To provide a GLP-1 analogue which is used for treating a mammal with a defective absorption syndrome such as diabetes, obesity, kidney dysfunction, or hypoglycemia and is more active or metabolically stable than a native glucagon-like peptide-1 (7-36) amide (GLP-1).

SOLUTION: A peptide analogue of a glucagon-like peptide-1 consisting of a specific amino acid sequence is provided, and so is a medicine composition which contains an effective amount of a pharmaceutically allowable salt of the peptide analogue and a pharmaceutically allowable carrier or diluent.

COPYRIGHT: (C)2006,JPO&NCIPI

(JA)

【課題】糖尿病、肥満、腎不全、低血糖症などの吸収不全症候群の哺乳動物を治療するための、ネーティブなグルカゴン様ペプチド−1(7−36)アミド(GLP−1)より活性であるか又はより代謝的に安定であるGLP−1類似体の提供。
【解決手段】特定なアミノ酸配列からなるグルカゴン様ペプチド−1のペプチド類似体、及びその製剤的に許容される塩の有効量と製剤的に許容される担体まはた希釈剤を含んでなる医薬組成物の提供。
【選択図】なし