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1. JP2005510232 - 再プログラムされたヒト体細胞核ならびに自系および同系なヒト幹細胞の製造および使用方法

Office
Japan
Application Number 2003547576
Application Date 26.11.2002
Publication Number 2005510232
Publication Date 21.04.2005
Publication Kind A
IPC
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10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
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A61K 35/28
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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48Reproductive organs
A61P 5/50
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5Drugs for disorders of the endocrine system
48of the pancreatic hormones
50for increasing or potentiating the activity of insulin
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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CPC
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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5Drugs for disorders of the endocrine system
48of the pancreatic hormones
50for increasing or potentiating the activity of insulin
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NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
873Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
Applicants アドバンスド セル テクノロジー、インク.
Inventors シベリ、ホセ
ウエスト、マイケル
キャンベル、キース
Agents 特許業務法人池内・佐藤アンドパートナーズ
Priority Data 60/332,510 26.11.2001 US
Title
(JA) 再プログラムされたヒト体細胞核ならびに自系および同系なヒト幹細胞の製造および使用方法
Abstract
(JA)

治療上のクローニングによって製造される活性化ヒト胚は、治療的移植片を得るための自系細胞からヒト分化全能および分化多能性幹細胞を生じさせることができる。本発明は、移植に適切な自系細胞または組織を得ることができる分化全能および分化多能性幹細胞の発生に用いることができる活性化ヒト胚を製造するための方法を提供する。実施形態の一つにおいて、本発明は、単為生殖による活性化ヒト胚の製造方法を提供し、別の実施形態において、本発明は、分化したヒトドナー細胞の前記遺伝物質は、治療的移植片のための自系、同系な細胞から得られる前記幹細胞の発生を指示することができる2倍体ヒト前核を形成するために再プログラムされるところによる、体細胞核移植による活性化ヒト胚の製造方法を提供する。自系ヒト胚を創造するための前記能力は、再生治療において免疫拒絶の前記問題を克服するために用いることができる免疫適合性幹細胞を発生するために重要な工程を表す。本発明によって製造された前記活性化ヒト胚は、また、後成の刷り込みの前記分子メカニズムおよび胚形成と発達との前記遺伝的調節を特定および分析するためのモデルシステムを提供する。