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1. JP2004131473 - ANALOG OF GLP-1

Office Japan
Application Number 2003283316
Application Date 31.07.2003
Publication Number 2004131473
Publication Date 30.04.2004
Grant Number 3934092
Grant Date 30.03.2007
Publication Kind B2
IPC
C07K 14/605
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
605Glucagons
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
Applicants SOC DE CONSEILS DE RECHERCHES & D'APPLICATIONS SCIENTIFIQUES SAS
ソシエテ ド コンセイユ ド ルシェルシェ エ ダアップリカーション シャンティフィック (エス.セー.エール.アー.エス.)
Inventors DONG ZHENG XIN
ドン,ツェン・シン
Agents 社本 一夫
今井 庄亮
増井 忠弐
小林 泰
富田 博行
江尻 ひろ子
Priority Data 09/206,601 07.12.1998 US
60/111,255 07.12.1998 US
Title
(EN) ANALOG OF GLP-1
(JA) GLP-1の類似体
Abstract
(EN)

PROBLEM TO BE SOLVED: To provide an analog of GLP-1 useful for the treatment of diabetes, osteoporosis, neurodegenerative disease, hypertension, etc., and having higher activity or higher metabolic stability than the metabolically unstable native glucagon-like peptide-1 (GLP-1).

SOLUTION: The pharmaceutical composition useful for the treatment of mammals contains an active amount of a peptide analog of a glucagon-like peptide-1 or its pharmacologically permissible salt and a pharmacologically permissible carrier or diluent.

COPYRIGHT: (C)2004,JPO

(JA)

【課題】 糖尿病,骨粗そ症,神経変性疾患,高血圧等の治療に有用であって,代謝不安定なネーティブなグルカゴン様ペプチド−1(GLP−1)より活性であるか又はより代謝的に安定であるGLP−1類似体を提供する。
【解決手段】グルカゴン様ペプチド−1のペプチド類似体、その製剤的に許容される塩、哺乳動物を治療するためにそのような類似体を使用する方法、及びそのために有用な前記類似体を含んでなる医薬組成物を提供する。
【選択図】なし