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1. JP2002201167 - METHOD FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND AND PRODUCTION INTERMEDIATE

Office Japan
Application Number 2001329282
Application Date 26.10.2001
Publication Number 2002201167
Publication Date 16.07.2002
Publication Kind A5
IPC
C07C 231/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
08from amides by reaction at nitrogen atoms of carboxamide groups
C07C 225/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
225Compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly-bound oxygen atoms not being part of a -CHO group, e.g. amino ketones
20having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
C07C 225/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
225Compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly-bound oxygen atoms not being part of a -CHO group, e.g. amino ketones
22having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
C07C 235/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 235/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04the carbon skeleton being acyclic and saturated
18having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
24having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07D 215/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
Applicants TAKEDA CHEM IND LTD
武田薬品工業株式会社
Inventors MIZUNO MASAHIRO
水野 正博
YAMANO MITSUHISA
山野 光久
Agents 青山 葆
田中 光雄
Priority Data 2000329040 27.10.2000 JP
Title
(EN) METHOD FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND AND PRODUCTION INTERMEDIATE
(JA) 置換芳香族化合物の製造法および製造中間体
Abstract
(EN)

PROBLEM TO BE SOLVED: To provide a method for producing a substituted aromatic compound, by which problems on Smiles rearrangement reaction can be solved and by which various aromatic compounds useful as intermediates for producing medicines, agrochemicals or many general-purpose chemicals can efficiently be produced by the utilization of the Smiles rearrangement reaction.

SOLUTION: This method for producing the substituted aromatic compound represented by formula (II) (the ring A is an aromatic homogeneous or heterogeneous ring which may have one or more constituents; X is O or the like; Y is NR1 or the like; B is an aromatic homogeneous or heterogeneous ring which may have one or more substituents or ethylene group which may have one or more substituents) or its salt, comprising subjecting a compound represented by formula (I) or its salt to the Smiles rearrangement reaction, is characterized in that the Smiles rearrangement reaction is carried out in an amide-based solvent in the presence of a basic hyroxide.

COPYRIGHT: (C)2002,JPO

(JA)


【課題】 スマイルス転位反応における問題を解決し、
医薬、農薬、あるいは多くの汎用化学品の製造中間体と
して有用な種々の芳香族化合物を、スマイルス転位反応
を利用して効率よく製造する。


【解決手段】 式(I)


【化1】


[式中、A環は置換基を有していてもよい芳香族同素ま
たは複素環を示す。
Xは-O-などを、Yは-NR(1)-
などを示す。
Bは置換基を有していてもよい芳香族同素
または複素環、あるいは置換されていてもよいエチレン
基を示す。
]で表される化合物またはその塩をスマイル
ス転位反応に付す式(II)


【化2】


[式中、各記号は上記と同意義である。
]で表される置
換芳香族化合物またはその塩の製造法であって、塩基性
の水酸化物の存在下、アミド系溶媒中でスマイルス転位
反応を行うことを特徴とする、式(II)で表される置換
芳香族化合物またはその塩の製造法。