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1. (JP2009506982) 神経保護効果のある化合物

Office : Japan
Application Number: 2008518473 Application Date: 23.06.2006
Publication Number: 2009506982 Publication Date: 19.02.2009
Publication Kind : A
IPC:
C12N 15/09
A61K 35/76
A61K 38/00
A61K 35/12
A61K 48/00
A61P 25/00
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
76
Viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
CPC:
A61K 48/005
A61K 38/1875
Applicants: ティシュージーン,インク
Inventors: リ,クワン,ヒ
リー,ドゥク,コイン
イ,ヤンスー
ナウ,ムン,ジョン
キム,ヒョン,チユン
Agents: 庄司 隆
資延 由利子
大杉 卓也
曽我 亜紀
Priority Data: 60/595,342 23.06.2005 US
Title: (JA) 神経保護効果のある化合物
Abstract: front page image
(JA)

本出願は神経の変性を防止する方法を開示しており、その方法は、(a)トランスフォーミング増殖因子のスーパーファミリーのメンバーまたは神経栄養因子タンパク質をコードするDNA配列をプロモーターに機能的に連結して含む組換え体ウイルベクタースまたはプラスミドベクターを作り出すこと、(b)培養細胞群をこの組換え体ベクターでインビトロにてトランスフェクトして、その培養細胞群を得ること、および(c)傷害を受けた神経の近辺領域にそのトランスフェクト細胞群を移植し、傷害を受けた神経の近辺領域内において該DNA配列を発現させて神経の変性を防止すること、を特徴とする。
【選択図】 図1


Also published as:
KR1020080038310KR1020100074340EP1904113CN101232904CA2613551JP2014088425
KR1020130101595KR1020140132010ES2562243KR1020160021458DK1904113CN106177996
AU2006261889AU2010257453IN10145/DELNP/2007KR1020180057737WO/2007/002512