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1. (JP2004250439) THIENOPYRIMIDINE COMPOUND AND USE OF THE SAME

Office : Japan
Application Number: 2004020107 Application Date: 28.01.2004
Publication Number: 2004250439 Publication Date: 09.09.2004
Grant Number: 4039574 Grant Date: 30.01.2008
Publication Kind : B2
IPC:
C07D 495/4
A61K 31/519
A61P 1/0
A61P 5/4
A61P 13/8
A61P 15/0
A61P 15/8
A61P 15/18
A61P 17/10
A61P 17/14
A61P 25/28
A61P 35/0
A61P 35/4
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
02
of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
04
for decreasing, blocking or antagonising the activity of the hypothalamic hormones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
08
of the prostate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
08
for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
18
Feminine contraceptives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
10
Anti-acne agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
14
for baldness or alopecia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
Applicants: TAKEDA CHEM IND LTD
武田薬品工業株式会社; 大阪府大阪市中央区道修町四丁目1番1号
Inventors: CHO NOBUO
長 展生
IMADA MICHI
今田 岐
TOBITAKA TAKENORI
飛高 武憲
MIWA NORIHIRO
三輪 憲弘
KUSAKA MASAMI
日下 雅美
SUZUKI NOBUHIRO
鈴木 伸宏
Priority Data: 2003020854 29.01.2003 JP
2004020107 28.01.2004 JP
Title: (EN) THIENOPYRIMIDINE COMPOUND AND USE OF THE SAME
(JA) チエノピリミジン化合物およびその用途
Abstract:
(EN) PROBLEM TO BE SOLVED: To obtain a thienopyrimidine compound having gonadotropin-releasing hormone antagonism, and to obtain a medicament containing the same.

SOLUTION: The compound expressed by the formula [R1 is a 1-4C alkyl; R2 is (1) a five- to seven-membered nitrogen-containing heterocyclic radical which may have a substituent selected from (1') a halogen, (2') hydroxy, (3') a 1-4C alkyl, and (4') a 1-4C alkoxy, (2) phenyl which may have a substituent selected from (1') a halogen, (2') a 1-4C alkoxy-1-4C alkyl, (3') a mono 1-4C alkyl-carbamoyl-1-4C alkyl, (4') a 1-4C alkoxy, and (5') a mono 1-4C alkylcarbamoyl-1-4C alkoxy, or the like; R3 is a 1-4C alkyl; R4 is a 1-4C alkoxy, or the like; and (n) is an integer of 1 to 4] or its salt is provided in the specification.

COPYRIGHT: (C)2004,JPO&NCIPI
(JA)


【課題】性腺刺激ホルモン放出ホルモン拮抗作用を有するチエノピリミジン化合物およびそれを含有する医薬の提供。
【解決手段】式
【化1】
〔式中、R1はC1-4アルキル、R2は(1)(1')ハロゲン、(2')水酸基、(3')C1-4アルキル、(4')C1-4アルコキシから選ばれる置換基を有していてもよい5ないし7員の含窒素複素環基、(2)(1')ハロゲン、(2')C1-4アルコキシ-C1-4アルキル、(3')モノC1-4アルキル-カルバモイル-C1-4アルキル、(4')C1-4アルコキシおよび(5')モノC1-4アルキルカルバモイル-C1-4アルコキシから選ばれる置換基を有していてもよいフェニル等、R3はC1-4アルキル、R4はC1-4アルコキシ等、nは1ないし4の整数を示す。
〕で表される化合物またはその塩。
【選択図】なし


Also published as:
NO20053974PL378002PLP.378002MXPA/a/2005/007990KR1020050096171ZA2005/06611
IL169869BRPI0407082CO5590921EP1591446JP2008094846RU02331648
US20060160829US20080108623US20120071486CN1768065CA2514407ES2410814
US20140221381PT1591446NZ541772DK1591446AU2004207706BNRE/2013/0034
ID047.1556BRPI0407082WO/2004/067535