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1. (JP2016014070) GENE EXPRESSION AND PAIN

Office : Japan
Application Number: 2015207655 Application Date: 22.10.2015
Publication Number: 2016014070 Publication Date: 28.01.2016
Grant Number: 6082796 Grant Date: 27.01.2017
Publication Kind : B2
IPC:
A61K 31/713
C12N 15/09
A61K 48/00
A61P 25/04
A61P 29/00
A61P 43/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
04
Centrally acting analgesics, e.g. opioids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants: アダイニクス, インコーポレイテッド
Inventors: ジュリアン マメ
Agents: 山本 秀策
森下 夏樹
飯田 貴敏
石川 大輔
山本 健策
Priority Data: 60/917,583 11.05.2007 US
Title: (EN) GENE EXPRESSION AND PAIN
(JA) 遺伝子発現と疼痛
Abstract:
(EN) PROBLEM TO BE SOLVED: To provide gene expression and pain.

SOLUTION: Pain may be defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Chronic pain afflicts 40% of the U.S. population and is associated with numerous deleterious medical conditions. The present invention relates to double-stranded oligonucleotides, pharmaceutical compositions thereof, and use of such double-stranded oligonucleotides and pharmaceutical compositions to modulate nociceptive signaling in a cell or prevent and/or treat pain in a patient.

COPYRIGHT: (C)2016,JPO&INPIT
(JA)

【課題】遺伝子発現と疼痛の提供。
【解決手段】疼痛は実際の、もしくは潜在的な組織の損傷に関連する不快な感覚的および情動的経験として定義されるか、または、そのような損傷の観点において説明され得る。慢性疼痛は合衆国人口の40%が罹患しており、そして多くの有害な医学的状態と関連している。本発明は2本鎖オリゴヌクレオチド、その医薬組成物、ならびに細胞における侵害受容シグナル伝達を調節するか患者における疼痛を予防および/または処置するためのそのような2本鎖オリゴヌクレオチドおよび医薬組成物の使用に関する。
【選択図】図8


Also published as:
JP2010526541CA2723672JP2014198053EP2818550JP2016117775AU2008251320
DK2158316AU2014201462AU2016266076ES2619314EP3199635JP2017148074
PT2158316WO/2008/141308