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1. JOP/2014/0070 - PYRIDINYL AND FUSED PYRIDINYL TRIAZOLONE DERIVATIVES

Office
Jordan
Application Number P/2014/0070
Application Date 05.03.2014
Publication Number P/2014/0070
Publication Date 13.03.2019
Grant Number 3377
Grant Date 29.01.2019
Publication Kind B1
IPC
C07D 403/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
A61K 31/4725
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
4725containing further heterocyclic rings
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants تاكيدا فارماسوتيكال كمبني ليمتد
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventors كريستوفر سميث
Smith, Christopher
فونج اتش. فو
VU, Phong H.
جون ديفيد لوسون
LAWSON, John David
نيكولاس سكوراه
SCORAH, Nicholas
هايكسيا وانج
WANG, Haixia
مارك سابات
SABAT, Mark
Agents المحاميان ايمان جمعة وابراهيم الطهاروة
ATTORNE (EMAN JOMOA & IBRAHIM ALTAHRAWEH)
Priority Data 61/776,445 11.03.2013 US
Title
(AR) مشتقات بيريدينيل وبيريدينيل مندمج
(EN) PYRIDINYL AND FUSED PYRIDINYL TRIAZOLONE DERIVATIVES
Abstract
(AR)

يتعلق الاختراع الحالي بمركبات من الصيغة 1،أو ملح مقبول دوائيا من ذلك، حيث يكون R1، R2، R3، وR4 كما تحدد في المواصفة. يتعلق هذا الاكتشاف أيضا بمواد وطرق لتحضير مركبات من الصيغة 1، بتركيبات دوائية تحتويها، وبالاستخدام لمعالجة تفاعلات حساسية مفرطة من النوع I، أمراض مناعة ذاتية، اضطرابات التهابية، سرطان، واضطرابات انقسامية غير خبيثة وحالات أخرى مصاحبة مع BTK.

(EN)

Disclosed are compounds of Formula 1,or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating Type I hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with BTK.