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1. IN202117021552 - INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)

Office
India
Application Number 202117021552
Application Date 12.05.2021
Publication Number 202117021552
Publication Date 29.10.2021
Publication Kind A
IPC
A61K
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C07D
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
A61P
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
Applicants SYROS PHARMACEUTICALS, INC.
Inventors MARINEAU, Jason, J.
CHUAQUI, Claudio
BRADLEY, Michael
CIBLAT, Stephane
KABRO, Anzhelika
Priority Data 62/754398 01.11.2018 US
62/877189 22.07.2019 US
62/915983 16.10.2019 US
62/927469 29.10.2019 US
Title
(EN) INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)
Abstract
(EN) The present invention provides various compositions, including compounds of Formula (I) or (la), or a species thereof, and pharmaceutically acceptable salts, solvates (e.g., hydrates), stereoisomer, tautomers, isotopic and other specified forms thereof. Also provided are methods (or uses) and kits involving the compounds or pharmaceutically acceptable compositions containing them for treating or preventing a disease (e.g., a proliferative disease such as cancer) in a subject. Administration of a compound or pharmaceutical composition described herein is expected to inhibit cyclin-dependent kinase 7 (CDK7), and thereby, induce apoptosis in tumor cells in the subject.
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