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1. IN201947041989 - PYRIMIDINYL-PYRIDYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF TREATING IRE1-RELATED DISEASES AND DISORDERS

Office India
Application Number 201947041989
Application Date 17.10.2019
Publication Number 201947041989
Publication Date 25.10.2019
Publication Kind A
IPC
C07D 403/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
Applicants GENENTECH, INC.
Inventors BRAUN, Marie-Gabrielle
GIBBONS, Paul
LEE, Wendy
LY, Cuong
RUDOLPH, Joachim
SCHWARZ, Jacob
ASHKENAZI, Avi
FU, Leo
LAI, Tommy
WANG, Fei
BEVERIDGE, Ramsay
ZHAO, Liang
Priority Data PCT/CN2017/077059 17.03.2017 CN
Title
(EN) PYRIMIDINYL-PYRIDYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF TREATING IRE1-RELATED DISEASES AND DISORDERS
Abstract
(EN)
Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula (I) or (I") structure : or stereoisomers tautomers or pharmaceutically acceptable salts thereof and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula (I) or (I") compounds as well as methods of using such IRE1 modulators alone and in combination with other therapeutic agents for treating diseases or conditions that are mediated or dependent upon estrogen receptors.