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1. IN201948032752 - IMPROVED FORMS OF A P13K DELTA SELECTIVE INHIBITOR FOR USE IN PHARMACEUTICAL FORMULATIONS

Office
India
Application Number 201948032752
Application Date 13.08.2019
Publication Number 201948032752
Publication Date 18.10.2019
Publication Kind A
IPC
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
Applicants RHIZEN PHARMACEUTICALS SA
Inventors SWAROOP KUMAR
VENKATA SATYA
VAKKALANKA
Priority Data 2596/CHE/2014 27.05.2014 IN
2597/CHE/2014 27.05.2014 IN
Title
(EN) IMPROVED FORMS OF A P13K DELTA SELECTIVE INHIBITOR FOR USE IN PHARMACEUTICAL FORMULATIONS
Abstract
(EN) The present invention relates to solid state forms of a p-toluenesulfonic acid salt (PTSA) of the selective PI3K delta inhibitor (S)-2-(l-(4-amino-3-(3-fluor"o-4-isopropoxyphenyl)-lH-pyrazoloIS^-djpyrimidin-l-yOethyO-S-CS-fluorophenyO^H-chromen^-one (TGR-1202). The present invention also relates to methods of preparing the same, pharmaceutical compositions containing them, and methods of treating a PI3K kinase mediated disease or disorder, such as cancer, by administering the same.