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1. IN201947024921 - ANTIGEN-BINDING DOMAIN AND POLYPEPTIDE INCLUDING CONVEYING SECTION

Office
India
Application Number 201947024921
Application Date 24.06.2019
Publication Number 201947024921
Publication Date 05.07.2019
Publication Kind A
IPC
C12N 15/09
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
Applicants CHUGAI SEIYAKU KABUSHIKI KAISHA
Inventors IGAWA, Tomoyuki
ISHIKAWA, Hiroyuki
HIRONIWA, Naoka
Priority Data 2016-229794 28.11.2016 JP
Title
(EN) ANTIGEN-BINDING DOMAIN AND POLYPEPTIDE INCLUDING CONVEYING SECTION
Abstract
(EN) The present invention pertains to: a polypeptide that includes an antigen-binding domain and a conveying section having an inhibitory domain for inhibiting the antigen-binding activity of the antigen-binding domain and that has a half-life longer than that of the antigen-binding domain when existing alone; a production method and screening method for the polypeptide; a pharmaceutical composition containing the polypeptide; a production method and screening method for a single-domain antibody the antigen-binding activity of which is inhibited by being associated with a specific VL/VH/VHH; and a library of fused polypeptides including a single-domain antibody the antigen-binding activity of which is inhibited by being associated with a specific VL/VH/VHH.
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SG11201904813SThis application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.