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1. IN201817042743 - BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS

Office India
Application Number 201817042743
Application Date 14.11.2018
Publication Number 201817042743
Publication Date 01.02.2019
Publication Kind A
IPC
C07C 317/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
16having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
Applicants BRITISH COLUMBIA CANCER AGENCY BRANCH
THE UNIVERSITY OF BRITISH COLUMBIA
Inventors ANDERSEN, Raymond
SADAR, Marianne Dorothy
JlAN, Kunzhong
MAWJl, Nasrin R.
WANG, Jun
BANUELOS, Carmen Adriana
YANG, Yu-Chi
Priority Data 62/323196 15.04.2016 US
Title
(EN) BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS
Abstract
(EN)
Compounds having a structure of Formula I or a pharmaceutically acceptable salt tautomer or stereoisomer thereof wherein R1 R2 R3 R11a R11b R11c R11d and X are as defined herein are provided. Uses of such compounds for modulating androgen receptor activity imaging diagnostics in cancer and therapeutics and methods for treatment of subjects in need thereof including prostate cancer are also provided.