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1. IN201848032022 -  METHOD FOR PREPARING COMPOUND HAVING HIV INTEGRASE INHIBITORY ACTIVITY

Office
India
Application Number 201848032022
Application Date 27.08.2018
Publication Number 201848032022
Publication Date 07.09.2018
Grant Number 346248
Grant Date 07.09.2020
Publication Kind B
IPC
C07D 498/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
Applicants Shionogi & Co., Ltd.
Inventors SUMINO, Yukihito
OKAMOTO, Kazuya
MASUI, Moriyasu
YAMADA, Daisuke
IKARASHI, Fumiya
Priority Data 2010-175899 05.08.2010 JP
2010-277713 14.12.2010 JP
Title
(EN)  METHOD FOR PREPARING COMPOUND HAVING HIV INTEGRASE INHIBITORY ACTIVITY
Abstract
(EN) A method of producing a compound shown by formula (Yl) or formula (Y2), or a salt thereof: [Chemical formula 37](wherein Rx is carbocyclyl optionally substituted by substituent E, heterocyclyl optionallysubstituted by substituent E, carbocyclyl lower alkyl optionally substituted by substituent E, orheterocyclyl lower alkyl optionally substituted by subtituent E)comprising steps of:(StepC")reacting a compound shown by formula (Wl):[Chemical formula 38]with a compound shown by formula (V3), or a salt mereof: [Chemical formula 39]H2N R6d(V3) (wherein R^ is lower alkyl optionally substituted by substituent E, or lower alkenyl optionally substituted by substituent E)to obtain a compound shown by formula (W2), or a salt thereof: [Chemical formula 40](wherein R^ is lower alkyl optionally substituted by substituent E, or lower alkenyl optionallysubstituted by substituent E), and(StepD")reacting a compound shown by formula (W2) witii (i?)-3-amino-burane-l-ol or (S)-2-amino-propan-l-ol to obtain a compound shown by formula (W3) or formula (W4), or a salt diereof:[Chemical formula 41]