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1. IN201847010324 - ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY

Office
India
Application Number 201847010324
Application Date 21.03.2018
Publication Number 201847010324
Publication Date 30.03.2018
Publication Kind A
IPC
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Applicants ASTEX THERAPEUTI CS LIMITED
CANCER RESEARCH TECHNOLOGY LIMITED
Inventors CHESSARI, Gianni
HOWARD, Steven
BUCK, Ildiko Maria
CONS, Benjamin David
JOHNSON, Christopher Norbert
HOLVEY, Rhian Sara
REES, David Charles
ST. DENIS, Jeffrey David
TAMANINI, Emiliano
GOLDING, Bernard Thomas
HARDCASTLE, Ian Robert
CANO, Celine Florence
MILLER, Duncan Charles
NOBLE, Martin Edward Mäntylä
GRIFFIN, Roger John (deceased)
OSBORNE, James Daniel
PEACH, Joanne
LEWIS, Arwel
HIRST, Kim Louise
WHITTAKER , Benjamin Paul
WATSON, David Wyn
MITCHELL, Dale Robert
Priority Data 1517216.6 29.09.2015 UK
Title
(EN) ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY
Abstract
(EN) The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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