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1. IN201747042608 - SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

Office
India
Application Number 201747042608
Application Date 28.11.2017
Publication Number 201747042608
Publication Date 30.03.2018
Grant Number 301875
Grant Date 04.10.2018
Publication Kind B
IPC
C07D 215/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36Sulfur atoms
Applicants AURIGENE DISCOVERY TECHNOLOGIES LIMITED
Inventors RAVI KOTRABASAIAH Ujjinamatada
PANDIT Chetan
Priority Data 2448/CHE/2015 15.05.2015 IN
Title
(EN) SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS
Abstract
(EN) The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I) which are therapeutically useful as modulators of Retinoic acid receptor related orphan receptors (RORs) more particularly as ROR?? modulators. These compounds are useful in the treatment and prevention of diseases and/or disorder in particular their use in diseases and/or disorder mediated by ROR?? receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted tetrahydroquinolinone or related compounds of formula (I) together with a pharmaceutically acceptable carrier diluent or excipient therefor.
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