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1. IN201717016409 - SPIRO ISOQUINOLINE 1 4 PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

Office India
Application Number 201717016409
Application Date 10.05.2017
Publication Number 201717016409
Publication Date 13.10.2017
Publication Kind A
IPC
C07D 471/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
C07D 471/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12in which the condensed system contains three hetero rings
20Spiro-condensed systems
A61K 31/435
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
Applicants LABORATORIOS DEL DR. ESTEVE S.A.
Inventors ALMANSA ROSALES Carmen
GARCIA LOPEZ Monica
CAAMANO MOURE Ana Maria
Title
(EN) SPIRO ISOQUINOLINE 1 4 PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
Abstract
(EN)
The present invention relates to spiro isoquinoline 1 4 piperidine compounds having dual pharmacological activity towards both the sigma (s) receptor and the µ opiod receptor to processes of preparation of such compounds to pharmaceutical compositions comprising them and to their use in therapy in particular for the treatment of pain.

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