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1. IN201647042988 - IMPROVED FORMS OF A PI3K DELTA SELECTIVE INHIBITOR FOR USE IN PHARMACEUTICAL FORMULATIONS

Office
India
Application Number 201647042988
Application Date 16.12.2016
Publication Number 201647042988
Publication Date 13.01.2017
Grant Number 328766
Grant Date 01.01.2020
Publication Kind B
IPC
C07D 48/04
Applicants Rhizen Pharmaceuticals SA
Inventors SWAROOP KUMAR VENKATA SATYA VAKKALANKA
Priority Data 2596/CHE/2014 27.05.2014 IN
2597/CHE/2014 27.05.2014 IN
Title
(EN) IMPROVED FORMS OF A PI3K DELTA SELECTIVE INHIBITOR FOR USE IN PHARMACEUTICAL FORMULATIONS
Abstract
(EN) The present invention relates to solid state forms of a p-toluenesulfonic acid salt (PTSA) of the selective PI3K delta inhibitor (S)-2-(l-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1 H-pyrazolo[3,4-d]pyrimidin-1 -yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one (TGR-1202). The present invention also relates to methods of preparing the same, pharmaceutical compositions containing them, and methods of treating a PI3K kinase mediated disease or disorder, such as cancer, by administering the same.