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1. IN201637032425 - PRODRUGS OF SUCCINIC ACID FOR INCREASING ATP PRODUCTION

Office
India
Application Number 201637032425
Application Date 22.09.2016
Publication Number 201637032425
Publication Date 03.03.2017
Publication Kind A
IPC
C07D 31/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
31Heterocyclic compounds containing one or more pyridine rings none of which is condensed with any other ring
02Methods of preparation
04by ring closure
06from unsaturated aliphatic compounds and ammonia
C07C 69/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
34Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
40Succinic acid esters
C07C 69/708
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
67of saturated acids
708Ethers
Applicants NEUROVIVE PHARMACEUTICAL AB
Inventors ELMÉR Eskil
HANSSON Magnus Joakim
EHINGER Karl Henrik Johannes
MOSS Steven
Priority Data PA 2014 70187 08.04.2014 DK
Title
(EN) PRODRUGS OF SUCCINIC ACID FOR INCREASING ATP PRODUCTION
Abstract
(EN) The present invention provides novel cell permeable succinates and cell permeable precursors of succinate aimed at increasing ATP production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation a process to which high energy electrons are provided by the Kreb s cycle. Not all Kreb s cycle intermediates are readily permeable to the cellular membrane one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP output.
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