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1. IN201637032248 - NOVEL CELL PERMEABLE SUCCINATE COMPOUNDS

Office
India
Application Number 201637032248
Application Date 21.09.2016
Publication Number 201637032248
Publication Date 09.12.2016
Publication Kind A
IPC
A61K 31/225
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
225Polycarboxylic acids
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07C 32/25
Applicants NEUROVIVE PHARMACEUTICAL AB
Inventors ELMÉR Eskil
HANSSON Magnus Joakim
EHINGER Karl Henrik Johannes
MOSS Steven
Priority Data PA 2014 70190 08.04.2014 DK
Title
(EN) NOVEL CELL PERMEABLE SUCCINATE COMPOUNDS
Abstract
(EN) The present invention provides novel cell permeable succinates and cell permeable precursors of succinate aimed at increasing ATP production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation a process to which high energy electrons are provided by the Kreb s cycle. Not all Kreb s cycle intermediates are readily permeable to the cellular membrane one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP output.