IN201647009984 1 2 4 OXADIAZOLE DERIVATIVES AS IMMUNOMODULATORS

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India

Application Number 201647009984

Application Date 22.03.2016

Publication Number 201647009984

Publication Date 31.08.2016

Grant Number 317056

Grant Date 30.07.2019

Publication Kind B

IPC

Applicants AURIGENE DISCOVERY TECHNOLOGIES LIMITED

Inventors SASIKUMAR Pottayil Govindan Nair
RAMACHANDRA Muralidhara
NAREMADDEPALLI Seetharamaiah Setty Sudarshan

Priority Data 4011/CHE/2013 06.09.2013 IN

Title

(EN) 1 2 4 OXADIAZOLE DERIVATIVES AS IMMUNOMODULATORS

Abstract

(EN) The present invention relates to 1 2 4 oxadiazole and 1 2 4 thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signaling pathway. The invention also refers to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and 5 derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD 1 PD L1 or PD L2 and therapies using them.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
271	Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02	not condensed with other rings
06	1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
285	Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
01	Five-membered rings
02	Thiadiazoles; Hydrogenated thiadiazoles
04	not condensed with other rings
08	1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42	Oxazoles
424	condensed with heterocyclic ring systems, e.g. clavulanic acid

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
271	Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02	not condensed with other rings
06	1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
285	Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
01	Five-membered rings
02	Thiadiazoles; Hydrogenated thiadiazoles
04	not condensed with other rings
08	1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles

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1. IN201647009984 - 1 2 4 OXADIAZOLE DERIVATIVES AS IMMUNOMODULATORS