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1. IN7248/CHENP/2014 - IMMUNOMODULATING CYCLIC COMPOUNDS FROM THE BC LOOP OF HUMAN PD1

Office
India
Application Number 7248/CHENP/2014
Application Date 29.09.2014
Publication Number 7248/CHENP/2014
Publication Date 01.07.2016
Publication Kind A
IPC
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
Applicants AURIGENE DISCOVERY TECHNOLOGIES LIMITED
Inventors SASIKUMAR Pottayil Govindan Nair
RAMACHANDRA Muralidhara
Priority Data 1213/CHE/2012 29.03.2012 IN
Title
(EN) IMMUNOMODULATING CYCLIC COMPOUNDS FROM THE BC LOOP OF HUMAN PD1
Abstract
(EN) The present invention relates to novel cyclic compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also relates to derivative s of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD 1 PD L1 or PD L2 and therapies using them.