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1. IN634/DEL/2005 - AN IMPROVED PROCESS FOR THE PREPARATION OF 6-O-METHYL ERYTHROMYCIN A DERIVATIVE

Office India
Application Number 634/DEL/2005
Application Date 23.03.2005
Publication Number 634/DEL/2005
Publication Date 19.06.2009
Grant Number 273338
Grant Date 03.06.2016
Publication Kind B
IPC
C07H 17/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
Applicants IND-SWIFT LABORATORIES LIMITED
Inventors CHIDAMBARAM VENKATESWARAN SRINIVASAN
RAHUL SAXENA
PRANAV GUPTA
Title
(EN) AN IMPROVED PROCESS FOR THE PREPARATION OF 6-O-METHYL ERYTHROMYCIN A DERIVATIVE
Abstract
(EN)
The present invention relates to an improved process for the preparation of 6-0-methylerythromycin A derivatives, intermediates of clarithromycin, by selective methylation of erythromycin A derivative in a mixture of a acyclic or cyclic alkanes having C6-C10 carbon atoms, and a polar aprotic solvent using a methylating agent in the presence of a base under mild conditions.

Also published as
EP6728411
ESP200750057
MXMX/a/2007/011749