Processing

Please wait...

Settings

Settings

Goto Application

1. IN707/DELNP/2012 - MARKERS FOR ENDOMETRIAL CANCER

Office India
Application Number 707/DELNP/2012
Application Date 24.01.2012
Publication Number 707/DELNP/2012
Publication Date 19.06.2015
Publication Kind A
IPC
C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Applicants GEADIC BIOTEC AIE
Inventors ABAL POSADA MIGUEL
DOLL ANDREAS
GIL MORENO ANTONIO
MAES TAMARA
PEREZ CRISTINA
REVENTÓS PUIGJANER JAUME
ROSSELL ELISABET
Priority Data 09166398.9 24.07.2009 EP
Title
(EN) MARKERS FOR ENDOMETRIAL CANCER
Abstract
(EN)
The invention relates to the surprising finding that biomarkers corresponding to ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1 R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, S0CS2, and DCN are differentially expressed in control samples as compared to samples from patients having endometrial cancer and are therefore useful for detecting endometrial cancer. In particular these biomarkers having excellent sensitivity, specificity, and/or the ability to separate affected from non affected individuals. Furthermore, the inventors found that the differential expression of these biomarkers in primary endometrial cancer tumor tissue is correlated to their expression level in uterine fluid samples as compared to control values. Thus these biomarkers are robust in that they are found to be differentially expressed in several different types of samples from affected individuals.

Other related publications