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1. IN1228/CHENP/2014 - TECHNIQUE FOR CLEAVING OUT PART OF POLY(A) CHAIN AND/OR 3 TERMINAL SEQUENCE OF MRNA TO INHIBIT TRANSLATION REACTION

Office
India
Application Number 1228/CHENP/2014
Application Date 17.02.2014
Publication Number 1228/CHENP/2014
Publication Date 10.10.2014
Publication Kind A
IPC
C12N 15/09
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
A61K 31/710
Applicants Public University Corporation Yokohama City University
Yoshindo Inc.
Tokyo Institute of Technology
Inventors WADA Tadashi
TAKEDA Kei
HANDA Hiroshi
Priority Data 2011160512 22.07.2011 JP
Title
(EN) TECHNIQUE FOR CLEAVING OUT PART OF POLY(A) CHAIN AND/OR 3 TERMINAL SEQUENCE OF MRNA TO INHIBIT TRANSLATION REACTION
Abstract
(EN)
Provided is an artificial gene expression inhibition method which can be designed more readily compared with conventional methods (an RNAi method a ribozyme method an antisense method) and in which the effect thereof can be confirmed readily. Provided are: a method for inhibiting the translation reaction of a target gene which comprises cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA; a kit for inhibiting a translation reaction which comprises a reagent capable of cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA; a cell into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene; and a non human living organism into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene.