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1. IN6027/CHENP/2012 - FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS

Office
India
Application Number 6027/CHENP/2012
Application Date 09.07.2012
Publication Number 6027/CHENP/2012
Publication Date 03.01.2014
Grant Number 297952
Grant Date 29.06.2018
Publication Kind B
IPC
C07D 47/04
C07D 48/04
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
Applicants TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventors ARIKAWA Yasuyoshi
JONES Benjamin
LAM Betty
NIE Zhe
SMITH Christopher
TAKAHASHI Masashi
DONG Qing
FEHER Victoria
Priority Data 61/289, 969 23.12.2009 US
61/386, 964 27.09.2010 US
Title
(EN) FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS
Abstract
(EN) Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof wherein G L L R R R and R are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1 pharmaceutical compositions containing them and their use for treating disorders diseases and conditions involving the immune system and inflammation including rheumatoid arthritis hematological malignancies epithelial cancers (i.e. carcinomas) and other disorders diseases and conditions for which inhibition of SYK is indicated.
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