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1. IN8528/DELNP/2012 - THERAPEUTIC DLL4 BINDING PROTEINS

Office India
Application Number 8528/DELNP/2012
Application Date 28.09.2012
Publication Number 8528/DELNP/2012
Publication Date 21.03.2014
Publication Kind A
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C07K 16/18
Applicants ABBVIE INC.
Inventors LI Yingchun
GU Jijie James
MORGAN LAPPE Susan
CHEN Mingjiu
HSIEH Chung Ming
Priority Data 61/309494 02.03.2010 US
Title
(EN) THERAPEUTIC DLL4 BINDING PROTEINS
Abstract
(EN)
DLL4 binding proteins are described herein including antibodies CDR grafted antibodies humanized antibodies and DLL4 binding fragments thereof proteins that bind DLL4 with high affinity and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.