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1. (IN4420/CHENP/2011) DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS

Office : India
Application Number: 4420/CHENP/2011 Application Date: 22.06.2011
Publication Number: 4420/CHENP/2011 Publication Date: 14.09.2012
Publication Kind : A
Prior PCT appl.: Application Number:PCTEP2009067026 ; Publication Number:WO2010072597A1 Click to see the data
IPC:
C07D 40/12
A61K 31/44
C07D 41/12
[IPC code unknown for C07D 40/12]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
[IPC code unknown for C07D 41/12]
Applicants: F. HOFFMANN-LA ROCHE AG
Inventors: BERGER, JACOB
CAROON, JOAN, MARIE
KRAUSS, NANCY, ELISABETH
LOPEZ-TAPIA, FRANCISCO JAVIER
WALKER, KEITH, ADRIAN, MURRAY
ZHAO, SHU-HAI
Priority Data: 61/203,482 23.12.2008 US
Title: (EN) DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
Abstract:
(EN) Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
Also published as:
AR074843IL213417MXMX/a/2011/006232SG172336EP2385939JP2012513433
CN102264723CA2745864MX2011006232KR1020110086768AU2009331659WO/2010/072597